Parenteral nutrition related cholestasis: infection as the main risk factor

Parenteral nutrition associated cholestasis

Parenteral nutrition (PN) is life saving for many preterm infants and other neonates with severe illness, but prolonged use of PN can lead to intrahepatic cholestasis, referred to as parenteral nutrition–associated cholestasis (PNAC). It is defined as direct bilirubin greater than 2.0 mg/dL persistent for at least 2 consecutive tests duringthe administration of PN, not associated with other kno...

Effect of S-adenosylmethionine on total parenteral nutrition-associated cholestasis

Methods: Twenty-four newborn rabbits were randomly divided into 3 groups: normal control group receiving breast milk, TPN group receiving TPN at a dose of 200 kcal/kg per day, and SAMe group receiving TPN plus SAMe at an intravenous dose of 100 mg/kg per day. Blood and liver samples were collected one week later. The levels of serum bile acid, alanine aminotransferase (ALT), alkaline phosphatas...

Total Parenteral Nutrition – Associated Cholestasis (TPNAC) in Newborns

Pediatrics Gastroenterologist & Master in Clinical Nutrition, Chief of Pediatrics Gastroenterology, Hepatology and Nutrition Department, Clínica del Niño PREVIANDES & Professor of Pediatric Gastroenterology & Pediatric Department Universidad El Bosque, Master in Clinical Nutrition and Professor of Pediatric Gastroenterology & Pediatric Department Universidad El Bosque, Pediatrician visitors Cor...

Analysis of risk factors for catheter-related bloodstream infection in a parenteral nutrition population

[Incidence of catheter-related infection and associated risk factors in hospitalized patients with parenteral nutrition].

INTRODUCTION The most severe complication of parenteral nutrition (PTN) is catheter-related infection (CRI). OBJECTIVES To study the incidence rate and factors associated to CRI. MATERIAL AND METHODS 271 patients followed at the Nutrition Unit for 6 months. The composition of the PTN was calculated according to the metabolic demands. 20.3% received a lipid solution enriched with omega-3 fat...